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OUTLINE: This is a randomized, double-blind, placebo-controlled, multicenter study.Patients are stratified according to disease type (breast vs colorectal female vs colorectal male), age (49 and under vs 50-69 vs 70 and over), ECOG performance status (0-1 vs 2), baseline quality of life (UNISCALE rating less than 50% vs 50-75% vs more than 75%), and concurrent chemotherapy (yes vs no). Choosing to participate in a study is an important personal decision.Colon and rectal cancer cases were defined using the International Classification of Disease version 10 (colon: C18.0⿿18.9, rectal: 19.9 and 20.9).Only cancers classified as adenocarcinomas were included in the analyses.The colon is a muscular tube 1.5 m long, and the rectum is 12-15 cm long.The rectum opens to the outside through the anal canal, which is 2-5 cm long.

For rectal cancer a significant association was not observed for birth weights below 3.5 kg.Talk with your doctor and family members or friends about deciding to join a study.To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.However, the clinical evidence and the underlying mechanism for this association are still inconclusive.We conducted a population-based study to further clarify this association.

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OUTLINE: This is a randomized, double-blind, placebo-controlled, multicenter study.