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Embryo splitting in which zygote divide asexually, to produce identical children, is blocked by mitosis inhibitor.

Surgery to separate conjoined twins may range from very easy to very difficult depending on the point of attachment and the internal parts that are shared.

Ms Formosa, 35, said the twins were “very excited” to be starting school.

“Four years ago it wasn't in my mind that this would ever happen,” she told the Press Association.

The most famous pair of conjoined twins was Chang and Eng Bunker (Thai: อิน-จัน, In-Chan) (1811–1874), Thai brothers born in Siam, now Thailand. Chang and Eng were joined by a band of flesh, cartilage, and their fused livers at the torso.

In modern times, they could have been easily separated.

Heather, a former nanny, married Riley, the “love of my life,” in October 2015.

So we are waiting to see exactly what that means,” their mother wrote on her blog a week after the procedure. Yes, the girls got separated, but this is only the beginning.” Neither the hospital nor the North Carolina couple has granted interviews since their disclosure on Tuesday that the conjoined twins were separated last week.

But their parents, Heather and Riley, are acutely aware that the hardest part of their medical odyssey is likely ahead.

Only time will tell whether the babies’ complex separation surgery at Children’s Hospital of Philadelphia left them with complications that could include neurological damage.

“Riley and I already love our children more than we could possibly imagine, and that is what makes it so hard,” she wrote in March 2016, shortly after an ultrasound at 11 weeks of pregnancy revealed she was carrying conjoined twins.

“We are choosing to believe that God has a plan for them, and it is to prosper them and give them hope and a future,” added the mother, who closes each post with prayer requests.

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