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Low-level activation of the "bad," inflammatory COX enzymes is essential for normal healing of tissues after injury or just plain routine wear-and-tear repairs.

-adrenergic agonist, used as a large animal sedative, primarily used in horses.

Chemotherapy must be administered by a veterinarian.

So far, so good, but it turns out that horses also need COX enzymes for normal kidney function, for secretion of the protective lining that shields the intestines from damage and for production of blood cells.These drugs should not be used with horses who have certain health problems including heart disease, respiratory dysfunction, seizures, or those who are in shock.Further, the heart rate is dramatically slowed, and some horses will faint after begin given a dose.The alpha-2 adregenic agonists (A2As) work more quickly, taking effect within five minutes, so tend to be preferred by vets. A2As are often recommended for procedures that might cause the horse pain, because they have an analgesic effect, and are often used in horses with colic.Side effects include salivation, sweating, diarrhea, elevated blood glucose, decreased intestinal motility, and the risk of early labour with retained placenta, if given to a pregnant mare in the last trimester of pregnancy.

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"There was a lot of hurt and anger."Much of it came from Jolie, who deliberately distanced herself from Voight in her adult years. Voight recalls one year at the Oscars – 1986 – when he was up for Best Actor for his ruthless bank-robber in Runaway Train and was expected to win. And my daughter to my left put her hand on my arm and said, 'Don't worry Dad, you're wonderful! And she's a good director now too."Much was made recently when Jolie accepted the Jean Hersholt Humanitarian Award in Hollywood for her charitable work, singling out her late mother in her acceptance speech and ignoring her father (who was in the audience).

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